"Recent data suggest that newer noninvasive tests such as the AmniSure^® ROM test may replace traditional clinical tests (nitrazine, pooling, and ferning) and amnio-dye tests in the diagnosis of preterm PROM."

Reviews In Obstetrics & Gynecology, Winter 2008. Caughey, AB, et al "AmniSure^® does not require the speculum examination used routinely for evaluation of ROM, and can serve as one test that covers the entire spectrum of diagnostic necessity - from simple cases where confirmatory diagnosis is needed to the most difficult cases where no visible leakage of amniotic fluid is evident or detectable by standard methods (sub-clinical rupture)."

American Journal of Perinatology, June 2005. Larry Cousins et al "Indeed, the placental [AmniSure^® ] immunoassay was noted to be positive in the majority of women who were later shown to have ROM but in whom standard clinical tests were negative."

Journal of Obstetrics and Gynecology, March 2007, Lee et al